Wellbutrin (bupropion) is a commonly prescribed antidepressant used to treat depression and anxiety. While it can be highly effective, stopping Wellbutrin suddenly or reducing the dose too quickly may lead to withdrawal symptoms.
Wellbutrin withdrawal symptoms can vary from person to person, but understanding them can help you prepare and manage the process more smoothly.
If you’re struggling with withdrawal symptoms or need support while transitioning off Wellbutrin, our mental health treatment programs can help.
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What is Wellbutrin?
Wellbutrin (bupropion) is an antidepressant medication primarily used to treat major depressive disorder and seasonal affective disorder, and as an aid for smoking cessation.
Unlike many other antidepressants that work by affecting serotonin levels, Wellbutrin works by inhibiting the reuptake of dopamine and norepinephrine in the brain, which helps regulate mood and behavior. I
t’s often prescribed for patients who haven’t responded well to other antidepressants or for those who wish to avoid certain side effects common with SSRIs, such as sexual dysfunction or weight gain.
Wellbutrin comes in different formulations, including immediate-release, sustained-release (SR), and extended-release (XL), allowing for once-daily or twice-daily dosing depending on the specific prescription.
As with any prescription medication, Wellbutrin should only be taken under the supervision of a healthcare provider, as it may cause side effects and has certain contraindications, particularly for people with seizure disorders or eating disorders.
What Causes Wellbutrin Withdrawal?
Unlike other antidepressants, Wellbutrin affects dopamine and norepinephrine rather than serotonin. This means its withdrawal symptoms can be different from those caused by other medications. Withdrawal happens when your brain needs time to adjust to lower levels of these neurotransmitters.
Stopping Wellbutrin too quickly can cause unpleasant effects, which is why doctors recommend a gradual tapering schedule to minimize discomfort.
Common Wellbutrin Withdrawal Symptoms
Wellbutrin withdrawal symptoms can be physical, emotional, and cognitive.
Common withdrawal symptoms include:
- Increased anxiety or irritability
- Depressive feelings
- Mood swings
- Fatigue or low energy
- Headaches
- Dizziness
- Nausea or stomach discomfort
- Difficulty concentrating
- Brain fog
- Confusion
- Insomnia
- Vivid dreams or nightmares
Not everyone experiences all of these symptoms, and their intensity varies based on factors like dosage and how long you’ve been taking Wellbutrin.
How Long Do Wellbutrin Withdrawal Symptoms Last?
The timeline for Wellbutrin withdrawal is different for everyone, but here’s a general breakdown:
Intermediate Phase – Week 1-2:
As withdrawal continues into the first and second weeks, some symptoms may intensify while others begin to emerge.
This period often brings heightened emotional distress, with mood swings, depression, and anxiety becoming more prominent.
Many people report experiencing “brain zaps” – brief, electric shock-like sensations in the head that can be disorienting and uncomfortable. Concentration difficulties and “brain fog” can make daily tasks challenging.
Appetite changes are common during this phase, with some people experiencing reduced hunger while others may have increased cravings, particularly for carbohydrates.
Initial Phase – First few days
Wellbutrin withdrawal typically begins within 24-72 hours after the last dose. During these first few days, patients may experience the onset of what’s often called “discontinuation syndrome.”
Symptoms can include irritability, anxiety, headaches, and dizziness. Sleep disturbances often emerge quickly, with insomnia or vivid dreams being common complaints. Some people report feeling generally unwell, with flu-like symptoms such as fatigue, muscle aches, and chills.
Extended Phase: Week 3 and Beyond
For most people, withdrawal symptoms begin to gradually subside during the third week and beyond, though the timeline varies considerably between individuals.
Cognitive functions start to improve, with concentration and mental clarity slowly returning to baseline. However, some individuals experience what’s known as “protracted withdrawal,” where certain symptoms – particularly those affecting mood and energy levels – persist for months.
During this extended phase, many people report a gradual return to their pre-Wellbutrin baseline, though some may find that certain symptoms, such as depression, return or worsen, indicating that the original condition being treated has reemerged. This phase often requires continued support and potentially consideration of alternative treatments if the original mental health condition remains problematic.
Tips for Managing Wellbutrin Withdrawal
If you’re coming off Wellbutrin, here are some ways to ease the transition:
- Follow Your Doctor’s Plan – A gradual dose reduction is safer than stopping suddenly.
- Stay Hydrated and Eat Well – Good nutrition and hydration support brain function and energy levels.
- Get Enough Rest – Prioritize sleep to help your body adjust.
- Exercise and Relaxation – Gentle activities like walking, yoga, or meditation can help manage stress.
- Seek Professional Support – A therapist or mental health provider can guide you through the process.
Do You Need Help with Wellbutrin Withdrawal?
Wellbutrin Withdrawal can be tough, but you don’t have to do it alone.
Peachtree Wellness Mental Health offers compassionate care and personalized support to help you through every step of your recovery.
Contact us today to get the help you need.
